Detalhe da pesquisa
1.
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Cell
; 161(6): 1252-65, 2015 Jun 04.
Artigo
Inglês
| MEDLINE | ID: mdl-26046436
2.
Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders.
Annu Rev Pharmacol Toxicol
; 64: 277-289, 2024 Jan 23.
Artigo
Inglês
| MEDLINE | ID: mdl-37552895
3.
Allosteric Modulators of Metabotropic Glutamate Receptors as Novel Therapeutics for Neuropsychiatric Disease.
Pharmacol Rev
; 74(3): 630-661, 2022 07.
Artigo
Inglês
| MEDLINE | ID: mdl-35710132
4.
Ventral Tegmental Area M5 Muscarinic Receptors Mediate Effort-Choice Responding and Nucleus Accumbens Dopamine in a Sex-Specific Manner .
J Pharmacol Exp Ther
; 385(2): 146-156, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36828630
5.
Metabotropic Glutamate Receptors As Emerging Targets for the Treatment of Schizophrenia.
Mol Pharmacol
; 101(5): 275-285, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35246479
6.
Discovery of a potent M5 antagonist with improved clearance profile. Part 2: Pyrrolidine amide-based antagonists.
Bioorg Med Chem Lett
; 78: 129021, 2022 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36228968
7.
Discovery of a potent M5 antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists.
Bioorg Med Chem Lett
; 76: 128988, 2022 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36113671
8.
Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor.
Bioorg Med Chem Lett
; 56: 128479, 2022 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34838649
9.
Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators.
Mol Psychiatry
; 25(11): 2786-2799, 2020 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30116027
10.
Increased Synaptic Strength and mGlu2/3 Receptor Plasticity on Mouse Prefrontal Cortex Intratelencephalic Pyramidal Cells Following Intermittent Access to Ethanol.
Alcohol Clin Exp Res
; 45(3): 518-529, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33434325
11.
Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes - Part 2.
Bioorg Med Chem Lett
; 53: 128416, 2021 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34710625
12.
Discovery and optimization of a novel CNS penetrant series of mGlu4 PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model.
Bioorg Med Chem Lett
; 37: 127838, 2021 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33556572
13.
Metabotropic glutamate receptor subtype 3 gates acute stress-induced dysregulation of amygdalo-cortical function.
Mol Psychiatry
; 24(6): 916-927, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29269844
14.
Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu2/4 heterodimeric receptor results in a compound with mGlu2/2 homodimer selectivity.
Bioorg Med Chem Lett
; 30(13): 127212, 2020 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32371100
15.
Synthesis and SAR of a series of mGlu7 NAMs based on an ethyl-8-methoxy-4-(4-phenylpiperazin-1-yl)quinoline carboxylate core.
Bioorg Med Chem Lett
; 30(22): 127529, 2020 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32890686
16.
Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M4 positive allosteric modulator (PAM) chemotype.
Bioorg Med Chem Lett
; 30(3): 126812, 2020 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31784320
17.
Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes.
Bioorg Med Chem Lett
; 30(4): 126811, 2020 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31787491
18.
Roles of the M4 acetylcholine receptor in the basal ganglia and the treatment of movement disorders.
Mov Disord
; 34(8): 1089-1099, 2019 08.
Artigo
Inglês
| MEDLINE | ID: mdl-31211471
19.
Surveying heterocycles as amide bioisosteres within a series of mGlu7 NAMs: Discovery of VU6019278.
Bioorg Med Chem Lett
; 29(10): 1211-1214, 2019 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30910459
20.
Further exploration of an N-aryl phenoxyethoxy pyridinone-based series of mGlu3 NAMs: Challenging SAR, enantiospecific activity and in vivo efficacy.
Bioorg Med Chem Lett
; 29(18): 2670-2674, 2019 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31358468